Imidazole → 1-(5-Bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropan-1-ol

HRID 829015Notes

Reaction equation

HRID 829015 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:15])[c:6]([CH:8]([C:9]([CH2:10][OH:11])([F:12])[F:13])[OH:14])[cH:7]1.[C:21]([CH3:22])([CH3:23])([CH3:24])[Si:25]([CH3:26])([CH3:27])[Cl:28].[CH2:32]([O:33][C:34](=[O:35])[CH3:36])[CH3:37].[CH3:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43].[Cl:29][CH2:30][Cl:31].[nH:16]1[cH:17][cH:18][n:19][cH:20]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:15])[c:6]([CH:8]([C:9]([CH2:10][O:11][Si:25]([C:21]([CH3:22])([CH3:23])[CH3:24])([CH3:26])[CH3:27])([F:12])[F:13])[OH:14])[cH:7]1

Participants

7

Reactant 6

HCID 795ImidazoleHCID 6344DichloromethaneHCID 8058HexaneHCID 8857Ethyl AcetateHCID 28928tert-Butyldimethylsilyl chlorideHCID 666662611-(5-Bromo-2-fluorophenyl)-2,2-difluoropropane-1,3-diol

Product 1

HCID 666654561-(5-Bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropan-1-ol

Sources & evidence

ORD record
ord-8ae998298e2e41f4b6fb64433c67af1d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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