Tetrahydrofuran → 8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl)-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 829129Notes

Reaction equation

[CH2:47]1[CH2:48][O:49][CH2:50][CH2:51][NH:52]1.[CH:1]([CH3:2])([CH3:3])[c:4]1[n:5][c:6]([CH2:9][CH2:10][c:11]2[cH:12][c:13]3[n:14]([c:15](=[O:44])[c:16](-[c:30]4[n:31][n:32][n:33][n:34]4[CH2:35][c:36]4[cH:37][cH:38][c:39]([O:42][CH3:43])[cH:40][cH:41]4)[c:17]([O:19][S:20]([c:21]4[cH:22][cH:23][c:24]([CH3:25])[cH:26][cH:27]4)(=[O:28])=[O:29])[n:18]3)[cH:45][cH:46]2)[s:7][cH:8]1.[O:53]1[CH2:54][CH2:55][CH2:56][CH2:57]1>>[CH:1]([CH3:2])([CH3:3])[c:4]1[n:5][c:6]([CH2:9][CH2:10][c:11]2[cH:12][c:13]3[n:14]([c:15](=[O:44])[c:16](-[c:30]4[n:31][n:32][n:33][n:34]4[CH2:35][c:36]4[cH:37][cH:38][c:39]([O:42][CH3:43])[cH:40][cH:41]4)[c:17]([N:52]4[CH2:47][CH2:48][O:49][CH2:50][CH2:51]4)[n:18]3)[cH:45][cH:46]2)[s:7][cH:8]1

Participants

Reactant 3

HCID 8028Tetrahydrofuran

HCID 8083Morpholine

HCID 220635268-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-tosyloxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 696031968-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl)-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

Sources & evidence

ORD record: ord-ba601f0ddc8941748a2a2c8856237e75
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…