Dichloromethane → 4-(piperidin-4-yl)-3,4-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-5(1H)-one

HRID 829352Notes

Reaction equation

HRID 829352 reaction equation
[Cl:27][CH2:28][Cl:29].[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36].[O:1]=[C:2]1[N:3]([CH:14]2[CH2:15][CH2:16][N:17]([C:20]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:26])[CH2:18][CH2:19]2)[CH2:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10][c:11]31)[nH:12][cH:13]2>>[O:1]=[C:2]1[N:3]([CH:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH2:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10][c:11]31)[nH:12][cH:13]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 49841655tert-Butyl 4-(5-oxopyrrolo[4,3,2-de][2,6]naphthyridin-4(1H,3H,5H)-yl)piperidine-1-carboxylate

Product 1

HCID 498416564-(piperidin-4-yl)-3,4-dihydropyrrolo[4,3,2-de][2,6]naphthyridin-5(1H)-one

Sources & evidence

ORD record
ord-699ba0beaa7c4e8aa9c392c8b0d0510a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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