Dichloromethane → 4-[1-Benzyl-3-(trifluoromethyl)pyrrolidin-3-yl]-2,6-bis(trifluoromethyl)pyridine

HRID 829405Notes

Reaction equation

HRID 829405 reaction equation
[CH2:21]([c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1)[N:28]([CH2:29][O:35][CH3:36])[CH2:32][Si:30]([CH3:31])([CH3:33])[CH3:34].[Cl:44][CH2:45][Cl:46].[F:1][C:2]([c:3]1[n:4][c:5]([C:15]([F:16])([F:17])[F:18])[cH:6][c:7]([C:9](=[CH2:10])[C:11]([F:12])([F:13])[F:14])[cH:8]1)([F:19])[F:20].[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[F:1][C:2]([c:3]1[n:4][c:5]([C:15]([F:16])([F:17])[F:18])[cH:6][c:7]([C:9]2([C:11]([F:12])([F:13])[F:14])[CH2:10][CH2:32][N:28]([CH2:21][c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[CH2:29]2)[cH:8]1)([F:19])[F:20]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 353442Benzyl(methoxymethyl)((trimethylsilyl)methyl)amineHCID 866646212,6-Bis(trifluoromethyl)-4-(3,3,3-trifluoroprop-1-en-2-yl)pyridine

Product 1

HCID 866749264-[1-Benzyl-3-(trifluoromethyl)pyrrolidin-3-yl]-2,6-bis(trifluoromethyl)pyridine

Sources & evidence

ORD record
ord-199505c033a44af494290b820042f3bb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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