Hydrochloric Acid → 4-(4-(3-chloro-4-fluorophenyl)-1-(2-(dimethylamino)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester

HRID 829678Notes

Reaction equation

HRID 829678 reaction equation
[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[N:15]1[CH2:16][CH2:17][CH:18]([c:21]2[nH:22][cH:23][c:24](-[c:26]3[cH:27][c:28]([Cl:33])[c:29]([F:32])[cH:30][cH:31]3)[n:25]2)[CH2:19][CH2:20]1.[CH3:36][S:37]([CH3:38])=[O:39].[Cl:2][CH2:3][CH2:4][N:5]([CH3:6])[CH3:7].[Cl:40][CH2:41][Cl:42].[ClH:1].[K+:35].[OH-:34]>>[CH2:3]([CH2:4][N:5]([CH3:6])[CH3:7])[n:22]1[c:21]([CH:18]2[CH2:17][CH2:16][N:15]([C:13]([O:12][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:14])[CH2:20][CH2:19]2)[n:25][c:24](-[c:26]2[cH:27][c:28]([Cl:33])[c:29]([F:32])[cH:30][cH:31]2)[cH:23]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 813Potassium CationHCID 961HydroxideHCID 6344DichloromethaneHCID 79012-Chloro-N,N-dimethylethylamineHCID 178451793HCID 178451793, compound

Product 1

HCID 672647824-(4-(3-chloro-4-fluorophenyl)-1-(2-(dimethylamino)ethyl)-1H-imidazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-0a60b10d2ff843a5885220bbe15c9970
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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