Dichloromethane → 4-[(4-Amino-1-piperidinyl)methyl]-3-fluoro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

HRID 829801Notes

Reaction equation

[Cl:37][CH2:38][Cl:39].[F:1][c:2]1[cH:3][n:4][c:5]2[cH:6][cH:7][c:8](=[O:29])[n:9]3[c:10]2[c:11]1[CH:12]([CH2:14][N:15]1[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]1)[CH2:13]3.[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36]>>[F:1][c:2]1[cH:3][n:4][c:5]2[cH:6][cH:7][c:8](=[O:29])[n:9]3[c:10]2[c:11]1[CH:12]([CH2:14][N:15]1[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]1)[CH2:13]3

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 866305801,1-Dimethylethyl {1-[(3-fluoro-7-oxo-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-4-yl)methyl]-4-piperidinyl}carbamate

Product 1

HCID 686864184-[(4-Amino-1-piperidinyl)methyl]-3-fluoro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one

Sources & evidence

ORD record: ord-10fa8ebef2864e96a663598c0d2be043
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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