反应详情

温度

70 °C

1-Chloroethyl chloroformate (180 μL, 1.6 mmol) was added to a solution of 1-benzhydryl-3-butoxyazetidine (370 mg, 1.2 mmol) in 1,2-dichloroethane (6 mL) at room temperature. The reaction mixture was then heated up to 70° C. and stirred for 1.5 hours. After cooling down to room temperature, methanol (7 mL) was added. The reaction mixture was again heated up to 70° C. and stirred for an additional 1.5 hours. After concentration to dryness, the crude mixture was triturated in pentane (2×5 mL) to give a yellow oil (179 mg, 86%) which was used in the next step without further purification.

1. temperatureAfter cooling down to room temperature
2. temperatureThe reaction mixture was again heated up to 70° C.
3. stirringstirred for an additional 1.5 hours
4. concentrationAfter concentration to dryness
5. customthe crude mixture was triturated in pentane (2×5 mL)