Acetate → 2-acetylamino-3-(4-amino-3-ethyl-phenyl)-acrylic Acid Benzyl Ester

HRID 829940Notes

Reaction equation

HRID 829940 reaction equation
[Br:24][c:25]1[cH:26][c:27]([CH2:32][CH3:33])[c:28]([NH2:29])[cH:30][cH:31]1.[C:1]([CH3:2])(=[O:3])[NH:4][C:5]([C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)=[CH2:16].[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH3:34][C:35]#[N:36].[O-:38][C:39]([CH3:40])=[O:41].[O-:42][C:43]([CH3:44])=[O:45].[Pd+2:37]>>[C:1]([CH3:2])(=[O:3])[NH:4][C:5]([C:6](=[O:7])[O:8][CH2:9][c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)=[CH:16][c:25]1[cH:26][c:27]([CH2:32][CH3:33])[c:28]([NH2:29])[cH:30][cH:31]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6342AcetonitrileHCID 8471TriethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 28012834-Bromo-2-ethylanilineHCID 14382052Benzyl 2-(acetylamino)acrylate

Product 1

HCID 699744002-acetylamino-3-(4-amino-3-ethyl-phenyl)-acrylic Acid Benzyl Ester

Sources & evidence

ORD record
ord-31f1fddd47b6490da1b8959917935230
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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