Hydrochloric Acid → HCID 67154562, compound

HRID 82997Notes

Reaction equation

HRID 82997 reaction equation
[ClH:1].[S:2]1[C:6]([CH2:7][O:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:5][N:4]=[CH:3]1>C(OCC)C>[ClH:1].[NH:11]1[CH2:12][CH:9]([O:8][CH2:7][C:6]2[S:2][CH:3]=[N:4][CH:5]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68338107tert-Butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate

Product 1

HCID 67154562HCID 67154562, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of HCl in diethylether (2N, 5.5 mL) was added to a solution of tert-butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate (150 mg, 0.55 mmol) in diethylether (2 mL) at room temperature. The reaction mixture was stirred 30 minutes then concentrated to dryness. After trituration in diethyl ether (10 mL), the title compound was obtained as a yellow solid (113 mg, quantitative).

Workup

  1. concentrationthen concentrated to dryness

Sources & evidence

ORD record
ord-9510d2764d074d5187948614dd01d133
Source dataset
uspto-grants-2014_09
Patent number
US08846711B2

Reaction notes

Loading…