反应详情

温度

60 °C

A mixture of conc. H2SO4 (15 mL) and water (15 mL) was treated with 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carbonitrile (5.0 g, 23.6 mmol), heated at 60° C. for 1 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo, and recrystallised (EtOAc/MeOH) to give the title compound (2.53 g, 47%) as a cream solid.

1. extractionextracted with EtOAc
2. dry with materialdried (MgSO4)
3. concentrationconcentrated in vacuo
4. customrecrystallised (EtOAc/MeOH)