HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 8300Generated: October 28, 2026
Water → 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid
https://huagongshe.com/reaction/8300
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 5-Amino-1-phenethyl-1H-pyrazole-4-carbonitrile | HCID 10608593 | — |
| Product | 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid | HCID 22015497 | 47% |
Reaction Steps
A mixture of conc. H2SO4 (15 mL) and water (15 mL) was treated with 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carbonitrile (5.0 g, 23.6 mmol), heated at 60° C. for 1 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo, and recrystallised (EtOAc/MeOH) to give the title compound (2.53 g, 47%) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07087754B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-e8cbd27a036f4845829de860836a32e9 |
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| Source note | uspto-grants-2006_08 |
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