Urea → HCID 178418810, compound

HRID 8301Notes

Reaction equation

HRID 8301 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:15]([OH:17])=O.[NH2:18][C:19](N)=[O:20]>O>[OH:20][C:19]1[N:1]=[C:2]2[N:6]([CH2:7][CH2:8][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:5]=[CH:4][C:3]2=[C:15]([OH:17])[N:18]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 220154975-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 178418810HCID 178418810, compoundYield 105%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid (1.87 g, 8.1 mmol) and urea (1.46 g, 24 mmol) was heated at 180° C. for 5 h, cooled and the resulting solid suspended in boiling water, filtered and washed with water to give the impure title compound (2.18 g, 105%,) as a cream solid.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. washwashed with water

Sources & evidence

ORD record
ord-ccb95d98398c434388eb28fcdff8e710
Source dataset
uspto-grants-2006_08
Patent number
US07087754B2

Reaction notes

Loading…