Hydrochloric Acid → 1'-{[5-(dimethylamino)pyridin-2-yl]methyl}-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 830379Notes

Reaction equation

HRID 830379 reaction equation
[Br:18][c:19]1[cH:20][cH:21][c:22]([CH2:25][N:26]2[C:27](=[O:47])[C:28]3([CH2:29][O:30][c:31]4[cH:32][c:33]5[c:34]([cH:39][c:40]43)[O:35][CH2:36][CH2:37][O:38]5)[c:41]3[cH:42][cH:43][cH:44][cH:45][c:46]32)[n:23][cH:24]1.[Br:48][c:49]1[cH:50][cH:51][c:52]([CH2:53][N:54]2[c:55]3[c:56]([cH:57][cH:58][cH:59][cH:60]3)[C:61]3([c:62]4[cH:63][c:64]([F:65])[c:66]([F:67])[cH:68][c:69]4[O:70][CH2:71]3)[C:72]2=[O:73])[cH:74][cH:75]1.[C:5]([N:6]1[CH2:7][CH2:8][CH:9]([NH2:10])[CH2:11]1)([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17].[CH3:2][NH:3][CH3:4].[ClH:1]>>[CH3:2][N:3]([CH3:4])[c:19]1[cH:20][cH:21][c:22]([CH2:25][N:26]2[C:27](=[O:47])[C:28]3([CH2:29][O:30][c:31]4[cH:32][c:33]5[c:34]([cH:39][c:40]43)[O:35][CH2:36][CH2:37][O:38]5)[c:41]3[cH:42][cH:43][cH:44][cH:45][c:46]32)[n:23][cH:24]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 27563701-Boc-3-aminopyrrolidineHCID 593524831'-(4-bromobenzyl)-5,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-oneHCID 59352743HCID 59352743, compound

Product 1

HCID 593526071'-{[5-(dimethylamino)pyridin-2-yl]methyl}-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-814a13198a784bf9873d74107cdb0b29
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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