Dichloromethane → 1-[(4-Tert-butylphenyl)methyl]-3-[[3-chloro-4-(methanesulfonamido)-5-methylphenyl]methyl]urea

HRID 830659Notes

Reaction equation

HRID 830659 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[c:17]1[cH:18][cH:19][c:20]([CH2:23][N:24]=[C:25]=[O:26])[cH:21][cH:22]1.[C:1]([c:2]1[cH:3][cH:4][c:5]([CH2:6][NH2:7])[cH:8][cH:9]1)([CH3:10])([CH3:11])[CH3:12].[CH2:42]([Cl:43])[Cl:44].[CH3:45][N:46]([c:47]1[cH:48][cH:49][n:50][cH:51][cH:52]1)[CH3:53].[NH2:27][CH2:28][c:29]1[cH:30][c:31]([Cl:41])[c:32]([NH:36][S:37](=[O:38])(=[O:39])[CH3:40])[c:33]([CH3:35])[cH:34]1>>[C:13]([CH3:14])([CH3:15])([CH3:16])[c:17]1[cH:18][cH:19][c:20]([CH2:23][NH:24][C:25](=[O:26])[NH:27][CH2:28][c:29]2[cH:30][c:31]([Cl:41])[c:32]([NH:36][S:37](=[O:38])(=[O:39])[CH3:40])[c:33]([CH3:35])[cH:34]2)[cH:21][cH:22]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 27356554-tert-ButylbenzylamineHCID 220422271-Tert-butyl-4-(isocyanatomethyl)benzeneHCID 67242390N-(4-Aminomethyl-2-chloro-6-methylphenyl)methanesulfonamide

Product 1

HCID 118516921-[(4-Tert-butylphenyl)methyl]-3-[[3-chloro-4-(methanesulfonamido)-5-methylphenyl]methyl]urea

Sources & evidence

ORD record
ord-21ab01918eb3460faad01ab3be885cab
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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