Hydrochloric Acid → N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-(2-amino-6-chloro-4-pyrimidinyl)amine

HRID 830829Notes

Reaction equation

HRID 830829 reaction equation
[ClH:29].[NH2:1][c:2]1[cH:3][c:4]([F:19])[c:5]([O:6][c:7]2[cH:8][cH:9][cH:10][c:11]3[c:12]2[c:13]([NH2:16])[n:14][o:15]3)[cH:17][cH:18]1.[NH2:20][c:21]1[n:22][c:23]([Cl:28])[cH:24][c:25]([Cl:27])[n:26]1.[OH2:30]>>[NH:1]([c:2]1[cH:3][c:4]([F:19])[c:5]([O:6][c:7]2[cH:8][cH:9][cH:10][c:11]3[c:12]2[c:13]([NH2:16])[n:14][o:15]3)[cH:17][cH:18]1)[c:25]1[cH:24][c:23]([Cl:28])[n:22][c:21]([NH2:20])[n:26]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 655222-Amino-4,6-dichloropyrimidineHCID 179792974-(4-Amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine

Product 1

HCID 17979320N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-(2-amino-6-chloro-4-pyrimidinyl)amine

Sources & evidence

ORD record
ord-02bc30416c2641349e8e6d432dbdf132
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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