Dichloromethane → (5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-yl)-[4-(1-hydroxy-1-methylethyl)piperidin-1-yl]methanone

HRID 831005Notes

Reaction equation

HRID 831005 reaction equation
[CH:54]([N:55]([CH2:56][CH3:57])[CH:58]([CH3:59])[CH3:60])([CH3:61])[CH3:62].[Cl:1][c:2]1[n:3][c:4]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([C:11](=[O:12])[OH:13])[n:10]2.[Cl:63][CH2:64][Cl:65].[NH:20]1[CH2:21][CH2:22][CH:23]([C:26]([CH3:27])([CH3:28])[OH:29])[CH2:24][CH2:25]1.[P-:30]([F:31])([F:32])([F:33])([F:34])([F:35])[F:36].[n:37]1([O:38][C:39]([N:40]([CH3:41])[CH3:42])=[N+:43]([CH3:44])[CH3:45])[c:46]2[n:47][cH:48][cH:49][cH:50][c:51]2[n:52][n:53]1>>[Cl:1][c:2]1[n:3][c:4]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([C:11](=[O:13])[N:20]1[CH2:21][CH2:22][CH:23]([C:26]([CH3:27])([CH3:28])[OH:29])[CH2:24][CH2:25]1)[n:10]2

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 52003212-(4-Piperidyl)-2-propanolHCID 866482365-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine-2-carboxylic acid

Product 1

HCID 59605242(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-yl)-[4-(1-hydroxy-1-methylethyl)piperidin-1-yl]methanone

Sources & evidence

ORD record
ord-373a7d20f007489f8d0fc6e1a045240b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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