反应详情

温度

57.5 °C

Epichlorohydrin (0.24 mL, 3.05 mmol) was added dropwise to a mixture of 1,3-dihydroxy-9H-thioxanthen-9-one (137 mg, 0.61 mmol) and K2CO3 (169 mg, 1.22 mmol) in anhydrous acetone (15 mL) in a dry round-bottom flask, followed by stirring under reflux at a temperature of 55 to 60° C. for one day. Solid of the reaction mixture was filtered and the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (developing solvent: CH2Cl2) to give the title compound (34 mg, 18.6%) as a yellow solid.

1. filtrationSolid of the reaction mixture was filtered
2. customthe solvent was removed under reduced pressure
3. customThe resulting residue was purified by silica gel column chromatography (developing solvent: CH2Cl2)