Dimethylformamide → 1-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenyl)-3-(2-(4-fluorophenyl)acetyl)urea

HRID 831091Notes

Reaction equation

HRID 831091 reaction equation
[Cl:32][CH2:33][Cl:34].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:10])[N:11]=[C:12]=[O:13])[cH:6][cH:7]1.[NH2:14][c:15]1[cH:16][c:17]([F:31])[c:18]([O:19][c:20]2[cH:21][c:22]([C:26](=[O:27])[NH2:28])[n:23][cH:24][cH:25]2)[cH:29][cH:30]1.[O:35]=[CH:36][N:37]([CH3:38])[CH3:39]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:10])[NH:11][C:12](=[O:13])[NH:14][c:15]2[cH:16][c:17]([F:31])[c:18]([O:19][c:20]3[cH:21][c:22]([C:26](=[O:27])[NH2:28])[n:23][cH:24][cH:25]3)[cH:29][cH:30]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 231530882-(4-Fluorophenyl)acetyl isocyanateHCID 231532054-(4-Amino-2-fluorophenoxy)picolinamide

Product 1

HCID 231531111-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenyl)-3-(2-(4-fluorophenyl)acetyl)urea

Sources & evidence

ORD record
ord-03c0e1601f8c4bb58a0c3960b80e982d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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