Toluene → 4-chloro-7-(2,4-dimethoxybenzyl)-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one

HRID 831135Notes

Reaction equation

HRID 831135 reaction equation
[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]([NH:13][CH2:14][c:15]2[c:16]([O:23][CH3:24])[cH:17][c:18]([O:21][CH3:22])[cH:19][cH:20]2)[c:7]1[CH2:8][C:9](=[O:10])[O:11][CH3:12].[c:25]1([CH3:26])[cH:27][cH:28][c:29]([S:30]([OH:31])(=[O:32])=[O:33])[cH:34][cH:35]1>>[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[c:7]1[CH2:8][C:9](=[O:10])[N:13]2[CH2:14][c:15]1[c:16]([O:23][CH3:24])[cH:17][c:18]([O:21][CH3:22])[cH:19][cH:20]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 6101p-Toluenesulfonic acidHCID 86641611Methyl 2-(4-chloro-6-(2,4-dimethoxybenzylamino)pyrimidin-5-yl)acetate

Product 1

HCID 569717344-chloro-7-(2,4-dimethoxybenzyl)-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one

Sources & evidence

ORD record
ord-5e8f0c93ccd24871915eef950d7d8b5a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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