1,2-Dichloroethane → 6-(3-amino-2-fluoropropyl)-9-chloro[1,2,4]triazolo[3,4-a]isoquinolin-3(2H)-one
Reaction equation
[CH2:1]([CH:2]=[CH2:3])[NH:4][CH2:5][CH:6]([CH2:7][c:8]1[cH:9][n:10]2[c:11]([c:12]3[cH:13][c:14]([Cl:18])[cH:15][cH:16][c:17]13)[n:19][nH:20][c:21]2=[O:22])[F:23].[CH2:24]([Cl:25])[CH2:26][Cl:27].[cH:28]1[cH:29][cH:30][c:31]([P:32]([Pd:33]([P:34]([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)([P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[P:72]([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)([c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)([c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)[c:97]2[cH:98][cH:99][cH:100][cH:101][cH:102]2)[cH:103][cH:104]1>>[NH2:4][CH2:5][CH:6]([CH2:7][c:8]1[cH:9][n:10]2[c:11]([c:12]3[cH:13][c:14]([Cl:18])[cH:15][cH:16][c:17]13)[n:19][nH:20][c:21]2=[O:22])[F:23]Participants
4
Sources & evidence
- ORD record
- ord-b47d2de89dfb4cd3be867a622c1d5d38
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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