Tetrahydrofuran → 3-(2,5-Difluoro-4-methyl-benzyloxy)-5-[3-(4-pyrrolidin-1-yl butyl)-ureido]-isothiazole-4-carboxylic acid amide

HRID 831473Notes

Reaction equation

HRID 831473 reaction equation
[N:30]1([CH2:35][CH2:36][CH2:37][CH2:38][NH2:39])[CH2:31][CH2:32][CH2:33][CH2:34]1.[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1.[c:1]1([O:2][C:8]([NH:9][c:10]2[c:11]([C:26]([NH2:27])=[O:28])[c:12]([O:15][CH2:16][c:17]3[c:18]([F:25])[cH:19][c:20]([CH3:24])[c:21]([F:23])[cH:22]3)[n:13][s:14]2)=[O:29])[cH:3][cH:4][cH:5][cH:6][cH:7]1>>[C:8]([NH:9][c:10]1[c:11]([C:26]([NH2:27])=[O:28])[c:12]([O:15][CH2:16][c:17]2[c:18]([F:25])[cH:19][c:20]([CH3:24])[c:21]([F:23])[cH:22]2)[n:13][s:14]1)(=[O:29])[NH:39][CH2:38][CH2:37][CH2:36][CH2:35][N:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 27627624-(Pyrrolidin-1-yl)butan-1-amineHCID 54330906[4-Carbamoyl-3-(2,5-difluoro-4-methyl-benzyloxy)-isothiazol-5-yl]carbamic acid phenyl ester

Product 1

HCID 539988383-(2,5-Difluoro-4-methyl-benzyloxy)-5-[3-(4-pyrrolidin-1-yl butyl)-ureido]-isothiazole-4-carboxylic acid amide

Sources & evidence

ORD record
ord-1842da92f6bc4892930c256050f714fc
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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