Dichloromethane → 3-(3,4-Difluorophenyl)pyrrolidin-3-ol

HRID 831585Notes

Reaction equation

HRID 831585 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][C:10]([OH:13])([c:14]2[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]2)[CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:29][CH2:30][Cl:31].[OH:22][C:23]([C:24]([F:25])([F:26])[F:27])=[O:28]>>[NH:8]1[CH2:9][C:10]([OH:13])([c:14]2[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]2)[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67405004Tert-butyl 3-(3,4-difluorophenyl)-3-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 635869723-(3,4-Difluorophenyl)pyrrolidin-3-ol

Sources & evidence

ORD record
ord-34364b051cfc4941bed818a23b82f224
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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