Sodium ion → 6,11-Dihydropyrrolo[2,1-c][1,4]benzodiazepin-5-yl-[4-(3-methoxy-2-methylcyclohexen-1-yl)-3-methylphenyl]methanone

HRID 831601Notes

Reaction equation

HRID 831601 reaction equation
[CH3:36][I:37].[H-:32].[H:34][H:35].[Na+:33].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[cH:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][N:7]([C:15](=[O:16])[c:17]1[cH:18][c:19]([CH3:31])[c:20]([C:23]3=[C:24]([CH3:30])[CH:25]([OH:29])[CH2:26][CH2:27][CH2:28]3)[cH:21][cH:22]1)[c:8]1[c:9]([cH:11][cH:12][cH:13][cH:14]1)[CH2:10]2>>[cH:1]1[cH:2][cH:3][n:4]2[c:5]1[CH2:6][N:7]([C:15](=[O:16])[c:17]1[cH:18][c:19]([CH3:31])[c:20]([C:23]3=[C:24]([CH3:30])[CH:25]([O:29][CH3:36])[CH2:26][CH2:27][CH2:28]3)[cH:21][cH:22]1)[c:8]1[c:9]([cH:11][cH:12][cH:13][cH:14]1)[CH2:10]2

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 166653HydrideHCID 10273123Racemic (10,11-Dihydro-5H-pyrrolo[2,1-c](1,4]benzodiazepin-10-yl)-[4-(3-hydroxy-2-methyl-cyclohex-1-en-1-yl)-3-methyl-phenyl]-methanoneHCID 178418361HCID 178418361, compound

Product 1

HCID 102960726,11-Dihydropyrrolo[2,1-c][1,4]benzodiazepin-5-yl-[4-(3-methoxy-2-methylcyclohexen-1-yl)-3-methylphenyl]methanone

Sources & evidence

ORD record
ord-d9ccf9fd2afe43e3abf831e422b7a595
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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