Dichloromethane → 3-[3-[4-[(3-Aminophenyl)methoxy]phenyl]-3-(1,2-oxazol-3-yl)propanoyl]-4-benzyl-1,3-oxazolidin-2-one

HRID 831803Notes

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH:8]1[N:9]([C:14]([CH2:15][CH:16]([c:17]2[n:18][o:19][cH:20][cH:21]2)[c:22]2[cH:23][cH:24][c:25]([O:26][CH2:27][c:28]3[cH:29][c:30]([NH:34][C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[cH:31][cH:32][cH:33]3)[cH:42][cH:43]2)=[O:44])[C:10](=[O:13])[O:11][CH2:12]1.[Cl:52][CH2:53][Cl:54].[F:45][C:46]([F:47])([F:48])[C:49]([OH:50])=[O:51]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[CH:8]1[N:9]([C:14]([CH2:15][CH:16]([c:17]2[n:18][o:19][cH:20][cH:21]2)[c:22]2[cH:23][cH:24][c:25]([O:26][CH2:27][c:28]3[cH:29][c:30]([NH2:34])[cH:31][cH:32][cH:33]3)[cH:42][cH:43]2)=[O:44])[C:10](=[O:13])[O:11][CH2:12]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 72251009tert-butyl N-[3-[[4-[3-(4-benzyl-2-oxo-1,3-oxazolidin-3-yl)-1-(1,2-oxazol-3-yl)-3-oxopropyl]phenoxy]methyl]phenyl]carbamate

Product 1

HCID 673305063-[3-[4-[(3-Aminophenyl)methoxy]phenyl]-3-(1,2-oxazol-3-yl)propanoyl]-4-benzyl-1,3-oxazolidin-2-one

Sources & evidence

ORD record: ord-d43f47e0676a4bd2a01a8c0b7c936cc5
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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