Sodium ion → Tert-butyl 4-(4-fluorophenyl)-2-((5-methylisoxazol-3-yl)methyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

HRID 831876Notes

Reaction equation

HRID 831876 reaction equation
[Br:28][CH2:29][c:30]1[n:31][o:32][c:33]([CH3:35])[cH:34]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][NH:10][C:11](=[O:25])[C:12]23[CH2:13][N:14]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:15][CH2:16][CH2:17]3)[cH:6][cH:7]1.[H-:26].[Na+:27].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][N:10]([CH2:29][c:30]3[n:31][o:32][c:33]([CH3:35])[cH:34]3)[C:11](=[O:25])[C:12]23[CH2:13][N:14]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:15][CH2:16][CH2:17]3)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 166653HydrideHCID 27763043-(Bromomethyl)-5-methylisoxazoleHCID 71060587HCID 71060587, compound

Product 1

HCID 71060659Tert-butyl 4-(4-fluorophenyl)-2-((5-methylisoxazol-3-yl)methyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

Sources & evidence

ORD record
ord-59307c5f1ea94f27924ed8a1634aa0d1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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