Hydrogen Bromide → 5,6-difluoro-1'-(pyridin-2-ylmethyl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 831895Notes

Reaction equation

HRID 831895 reaction equation
[Br:10][CH2:11][c:12]1[o:13][c:14]([C:15]([F:16])([F:17])[F:18])[cH:19][cH:20]1.[Br:2][CH2:3][c:4]1[n:5][cH:6][cH:7][cH:8][cH:9]1.[BrH:1].[CH3:41][c:42]1[c:43]2[cH:44][c:45]3[c:58]([cH:59][c:60]2[o:61][n:62]1)[O:57][CH2:56][C:46]31[c:47]2[c:48]([cH:49][cH:50][cH:51][cH:52]2)[NH:53][C:54]1=[O:55].[F:21][c:22]1[c:23]([F:40])[cH:24][c:25]2[c:26]([cH:39]1)[C:27]1([CH2:28][O:29]2)[C:30](=[O:38])[NH:31][c:32]2[cH:33][cH:34][cH:35][cH:36][c:37]21>>[CH2:3]([c:4]1[n:5][cH:6][cH:7][cH:8][cH:9]1)[N:31]1[C:30](=[O:38])[C:27]2([c:26]3[c:25]([cH:24][c:23]([F:40])[c:22]([F:21])[cH:39]3)[O:29][CH2:28]2)[c:37]2[c:32]1[cH:33][cH:34][cH:35][cH:36]2

Participants

6

Reactant 5

HCID 260Hydrogen BromideHCID 5642092-(Bromomethyl)pyridineHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 593524533-methylspiro[furo[3,2-f][1,2]benzisoxazole-5,3'-indol]-2'(1H)-oneHCID 593525695,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Product 1

HCID 593521425,6-difluoro-1'-(pyridin-2-ylmethyl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-efab95e00cb445c0b5ea31b6ef9b0dc3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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