proline dl-form → HCID 66620681, compound

HRID 831978Notes

Reaction equation

HRID 831978 reaction equation
[C:72]([CH:73]1[CH2:74][NH:75][CH:76]([C:77]([OH:78])=[O:79])[CH2:80]1)#[N:81].[CH3:1][O:2][C:3]([NH:4][CH:5]([CH:6]([CH3:7])[CH3:8])[C:9](=[O:10])[N:11]1[CH:12]([c:16]2[nH:17][c:18](-[c:21]3[cH:22][c:23]4[c:31]([cH:32][cH:33]3)-[c:30]3[c:25]([cH:26][c:27](-[c:34]5[cH:35][c:36]6[c:37]([n:38][c:39]([CH:41]7[N:42]([C:48]([CH:49]([CH:50]([CH3:51])[CH3:52])[NH:53][C:54](=[O:55])[O:56][CH3:57])=[O:58])[CH:43]8[CH2:44][CH2:45][CH:46]7[CH2:47]8)[nH:40]6)[cH:59][cH:60]5)[cH:28][cH:29]3)[C:24]4([F:61])[F:62])[cH:19][n:20]2)[CH2:13][CH2:14][CH2:15]1)=[O:63].[OH:64][C:65]([CH:66]1[CH2:68][CH2:67][CH2:70][NH:71]1)=[O:69]>>[CH3:1][O:2][C:3]([NH:4][CH:5]([CH:6]([CH3:7])[CH3:8])[C:9](=[O:10])[N:11]1[CH:12]([c:16]2[nH:17][c:18](-[c:21]3[cH:22][c:23]4[c:31]([cH:32][cH:33]3)-[c:30]3[c:25]([cH:26][c:27](-[c:34]5[cH:35][c:36]6[c:37]([n:38][c:39]([CH:41]7[N:42]([C:48]([CH:49]([CH:50]([CH3:51])[CH3:52])[NH:53][C:54](=[O:55])[O:56][CH3:57])=[O:58])[CH:43]8[CH2:44][CH2:45][CH:46]7[CH2:47]8)[nH:40]6)[cH:59][cH:60]5)[cH:28][cH:29]3)[C:24]4([F:61])[F:62])[cH:19][n:20]2)[CH2:13][CH:14]([C:70]#[N:71])[CH2:15]1)=[O:63]

Participants

4

Reactant 3

HCID 614proline dl-formHCID 22324540HCID 22324540, compoundHCID 66620162(1-{2-[5-(9,9-Difluoro-7-{2-[2-(2-methoxycarbonylamino-3-methyl-butyryl)-2-aza-bicyclo[2.2.1]hept-3-yl]-3H-benzoimidazol-5-yl]-9H-fluoren-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Product 1

HCID 66620681HCID 66620681, compound

Sources & evidence

ORD record
ord-1af965aece5645f0a5f408acccf91303
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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