Hydrochloric Acid → 4-(2,5-Difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine

HRID 832260Notes

Reaction equation

HRID 832260 reaction equation
[C:17]([Cl:18])(=[O:19])[CH2:20][CH:21]([CH3:22])[CH3:23].[CH2:40]([CH2:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)[S:48](=[O:49])(=[O:50])[Cl:51].[CH3:3][O:4][c:5]1[cH:6][cH:7][c:8]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:15][cH:16]1.[ClH:1].[ClH:2].[F:24][c:25]1[c:26]([N:34]2[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]2)[cH:27][c:28]([F:33])[c:29]([O:31][CH3:32])[cH:30]1>>[F:24][c:25]1[c:26]([N:34]2[CH2:35][CH2:36][N:37]([S:48]([CH2:40][CH2:41][c:42]3[cH:43][cH:44][cH:45][cH:46][cH:47]3)(=[O:49])=[O:50])[CH2:38][CH2:39]2)[cH:27][c:28]([F:33])[c:29]([O:31][CH3:32])[cH:30]1

Participants

6

Reactant 5

HCID 313Hydrochloric Acid2×HCID 66054Isovaleryl chlorideHCID 2697221-(4-Methoxyphenyl)piperazineHCID 27603742-Phenylethane-1-sulfonyl chlorideHCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

Product 1

HCID 231114704-(2,5-Difluoro-4-methoxyphenyl)-1-phenethylsulfonylpiperazine

Sources & evidence

ORD record
ord-9727e26335504c8f81dfe76edef147e5
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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