Bicarbonate Ion → 2-[(2,5-Dichloropyrimidin-4-yl)amino]cyclohexane-1-carboxamide

HRID 832285Notes

Reaction equation

HRID 832285 reaction equation
[CH3:25][OH:26].[CH3:28][CH2:29][O:30][C:31]([CH3:32])=[O:33].[Cl:11][c:12]1[n:13][cH:14][c:15]([Cl:19])[c:16]([Cl:18])[n:17]1.[NH2:1][CH:2]1[CH:3]([C:8](=[O:9])[NH2:10])[CH2:4][CH2:5][CH2:6][CH2:7]1.[Na+:24].[O-:20][C:21]([OH:22])=[O:23].[OH2:27]>>[NH:1]([CH:2]1[CH:3]([C:8](=[O:9])[NH2:10])[CH2:4][CH2:5][CH2:6][CH2:7]1)[c:16]1[c:15]([Cl:19])[cH:14][n:13][c:12]([Cl:11])[n:17]1

Participants

8

Reactant 7

HCID 769Bicarbonate IonHCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 8857Ethyl AcetateHCID 2372592,4,5-TrichloropyrimidineHCID 125125032-Aminocyclohexanecarboxamide

Product 1

HCID 723329072-[(2,5-Dichloropyrimidin-4-yl)amino]cyclohexane-1-carboxamide

Sources & evidence

ORD record
ord-4616d6ef6d4741d1ba6385b01066fca0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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