Methanol → 5-Bromo-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridine

HRID 832288Notes

Reaction equation

HRID 832288 reaction equation
[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:31][OH:32].[Cl:18][c:19]1[n:20][cH:21][c:22]([Br:25])[cH:23][cH:24]1.[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][o:10][c:11]([CH3:15])[c:12]2[CH2:13][OH:14])[cH:6][cH:7]1.[H-:16].[Na+:17].[OH2:33]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][o:10][c:11]([CH3:15])[c:12]2[CH2:13][O:14][c:19]2[n:20][cH:21][c:22]([Br:25])[cH:23][cH:24]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 166653HydrideHCID 27344145-Bromo-2-chloropyridineHCID 28473136(3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol

Product 1

HCID 684428165-Bromo-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridine

Sources & evidence

ORD record
ord-96f5ce2032314043b2ab5d83940e5e93
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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