Pyridine → Phenyl 2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate

HRID 832325Notes

Reaction equation

HRID 832325 reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[Cl:27][C:28](=[O:29])[O:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[NH2:7][c:8]1[c:9]([F:26])[cH:10][c:11]([O:12][c:13]2[cH:14][cH:15][n:16][c:17]3[nH:18][c:19](=[O:23])[cH:20][n:21][c:22]23)[cH:24][cH:25]1.[cH:1]1[cH:2][cH:3][n:4][cH:5][cH:6]1>>[NH:7]([c:8]1[c:9]([F:26])[cH:10][c:11]([O:12][c:13]2[cH:14][cH:15][n:16][c:17]3[nH:18][c:19](=[O:23])[cH:20][n:21][c:22]23)[cH:24][cH:25]1)[C:28](=[O:29])[O:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 8028TetrahydrofuranHCID 15891Phenyl chloroformateHCID 469009328-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 59588837Phenyl 2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate

Sources & evidence

ORD record
ord-e2c9d0b4493943bc9d9850256d5fa8f2
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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