Dichloromethane → 1-(2-Amino-1,3-thiazol-4-yl)propan-1-one

HRID 832603Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[s:9][cH:10][c:11]([C:13]([CH2:14][CH3:15])=[O:16])[n:12]1)([CH3:5])([CH3:6])[CH3:17].[Cl:25][CH2:26][Cl:27].[OH:18][C:19]([C:20]([F:21])([F:22])[F:23])=[O:24]>>[NH2:7][c:8]1[s:9][cH:10][c:11]([C:13]([CH2:14][CH3:15])=[O:16])[n:12]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 45117897tert-Butyl (4-propionylthiazol-2-yl)carbamate

Product 1

HCID 451216921-(2-Amino-1,3-thiazol-4-yl)propan-1-one

Sources & evidence

ORD record: ord-df5c30ea56e84dc28970c08e254c2461
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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