Trifluoroacetic acid → 7-O-tert-butyl 8-O-methyl 3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-3,6,8,9-tetrahydro-2H-[1,4]dioxino[2,3-g]isoquinoline-7,8-dicarboxylate

HRID 832947Notes

Reaction equation

HRID 832947 reaction equation
[CH3:1][O:2][C:3]([CH:4]([CH2:5][c:6]1[cH:7][c:8]2[c:9]([cH:30][cH:31]1)[O:10][CH:11]([c:14]1[cH:15][cH:16][c:17]([O:20][CH2:21][c:22]3[cH:23][c:24]([Cl:29])[c:25]([Cl:28])[cH:26][cH:27]3)[cH:18][cH:19]1)[CH2:12][O:13]2)[NH:32][C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40].[F:41][C:42]([F:43])([F:44])[C:45]([OH:46])=[O:47].[O:48]1[CH2:49][CH2:50][O:51][CH2:52][CH2:53]1>>[CH3:1][O:2][C:3]([CH:4]1[CH2:5][c:6]2[cH:7][c:8]3[c:9]([cH:30][c:31]2[CH2:42][N:32]1[C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[O:10][CH:11]([c:14]1[cH:15][cH:16][c:17]([O:20][CH2:21][c:22]2[cH:23][c:24]([Cl:29])[c:25]([Cl:28])[cH:26][cH:27]2)[cH:18][cH:19]1)[CH2:12][O:13]3)=[O:40]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 312751,4-DioxaneHCID 66719190Methyl 3-[2-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2,3-dihydro-1,4-benzodioxin-6-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

Product 1

HCID 667192887-O-tert-butyl 8-O-methyl 3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-3,6,8,9-tetrahydro-2H-[1,4]dioxino[2,3-g]isoquinoline-7,8-dicarboxylate

Sources & evidence

ORD record
ord-77e99efaeee7410ea562e7c5020b77fb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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