5-(2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-3-oxa-1,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide
Reaction equation
[Br:29][c:30]1[n:31][c:32]([CH2:33][N:37]2[CH2:38][CH2:39][C:40]3([CH2:41][O:42][C:43](=[O:45])[NH:44]3)[CH2:46][CH2:47]2)[cH:34][cH:35][cH:36]1.[F:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([C:26](=[O:27])[NH2:28])[c:15]([NH:17][c:18]3[n:19][c:20]([CH:24]=[O:25])[cH:21][cH:22][cH:23]3)[s:16]2)[cH:4][cH:5][c:6]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:7]1>>[F:1][c:2]1[c:3](-[c:12]2[cH:13][c:14]([C:26](=[O:27])[NH2:28])[c:15]([NH:17][c:18]3[n:19][c:20]([CH2:24][N:37]4[CH2:38][CH2:39][C:40]5([CH2:41][O:42][C:43](=[O:45])[NH:44]5)[CH2:46][CH2:47]4)[cH:21][cH:22][cH:23]3)[s:16]2)[cH:4][cH:5][c:6]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-8499857bebf34be8b4e2e9a1c191f8b3
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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