Hydrochloric Acid → 1-[3,5-Bis(trifluoromethyl)phenyl]-3-[3-(4-fluorophenyl)-1-[1-(2-hydroxyacetyl)piperidine-4-carbonyl]piperidin-4-yl]-1,3-dimethylurea
Reaction equation
[C:35]([CH2:36][OH:37])(=[O:38])[N:39]1[CH2:40][CH2:41][CH:42]([C:45](=[O:46])[OH:47])[CH2:43][CH2:44]1.[ClH:1].[F:2][C:3]([c:4]1[cH:5][c:6]([N:14]([C:15](=[O:16])[N:17]([CH3:18])[CH:19]2[CH:20]([c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[CH2:21][NH:22][CH2:23][CH2:24]2)[CH3:32])[cH:7][c:8]([C:10]([F:11])([F:12])[F:13])[cH:9]1)([F:33])[F:34]>>[F:2][C:3]([c:4]1[cH:5][c:6]([N:14]([C:15](=[O:16])[N:17]([CH3:18])[CH:19]2[CH:20]([c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[CH2:21][N:22]([C:45]([CH:42]3[CH2:41][CH2:40][N:39]([C:35]([CH2:36][OH:37])=[O:38])[CH2:44][CH2:43]3)=[O:46])[CH2:23][CH2:24]2)[CH3:32])[cH:7][c:8]([C:10]([F:11])([F:12])[F:13])[cH:9]1)([F:33])[F:34]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-f96e24f4f7674765bb20c2c2d4c47fae
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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