Dichloromethane → 4-(6-Fluoro-4-pyrido[3,4-d]pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester

HRID 833550Notes

Reaction equation

HRID 833550 reaction equation
[C:32]([CH3:33])([CH3:34])([CH3:35])[O:36][C:37](=[O:38])[N:39]1[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]1.[CH2:45]([Cl:46])[Cl:47].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[cH:8][n:9][c:10]([F:12])[cH:11]2.[F:13][c:14]1[n:15][cH:16][c:17]2[n:18][cH:19][nH:20][c:21](=[O:22])[c:23]2[cH:24]1>>[c:2]1([N:42]2[CH2:41][CH2:40][N:39]([C:37]([O:36][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:38])[CH2:44][CH2:43]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[cH:8][n:9][c:10]([F:12])[cH:11]2

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 106790414-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINEHCID 1354173706-fluoropyrido[3,4-d]pyrimidin-4-ol

Product 1

HCID 113934494-(6-Fluoro-4-pyrido[3,4-d]pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-434bd08b01814ba3879bd7b8f29e4e05
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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