Dichloromethane → 1-(3-((5-(2-ethyl-1H-benzo[d]imidazol-1-yl)-7-morpholinothiazolo[5,4-d]pyrimidin-2-yl)methyl)azetidin-1-yl)-2-hydroxy-2-methylpropan-1-one
Reaction equation
[CH:63]([N:64]([CH2:65][CH3:66])[CH:67]([CH3:68])[CH3:69])([CH3:70])[CH3:71].[Cl:72][CH2:73][Cl:74].[NH:1]1[CH2:2][CH:3]([CH2:5][c:6]2[s:7][c:8]3[n:9][c:10](-[n:21]4[c:22]([CH2:30][CH3:31])[n:23][c:24]5[c:25]4[cH:26][cH:27][cH:28][cH:29]5)[n:11][c:12]([N:15]4[CH2:16][CH2:17][O:18][CH2:19][CH2:20]4)[c:13]3[n:14]2)[CH2:4]1.[OH:32][C:33]([C:34](=[O:35])[OH:36])([CH3:37])[CH3:38].[P-:39]([F:40])([F:41])([F:42])([F:43])([F:44])[F:45].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[n:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[N:1]1([C:34]([C:33]([OH:32])([CH3:37])[CH3:38])=[O:35])[CH2:2][CH:3]([CH2:5][c:6]2[s:7][c:8]3[n:9][c:10](-[n:21]4[c:22]([CH2:30][CH3:31])[n:23][c:24]5[c:25]4[cH:26][cH:27][cH:28][cH:29]5)[n:11][c:12]([N:15]4[CH2:16][CH2:17][O:18][CH2:19][CH2:20]4)[c:13]3[n:14]2)[CH2:4]1Participants
7
Reactant 6
HCID 6344Dichloromethane
HCID 9886Hexafluorophosphate
HCID 116712-Hydroxyisobutyric acid
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 596054122-Azetidin-3-ylmethyl-5-(2-ethylbenzoimidazol-1-yl)-7-morpholin-4-ylthiazolo[5,4-d]pyrimidineProduct 1
Sources & evidence
- ORD record
- ord-6a9e82dbd1ed43f3adca4e19829cdfbb
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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