Ammonium → 4-(3-Chloro-4-fluoroanilino)-6-(1-imidazolyl)quinazoline

HRID 834428Notes

Reaction equation

HRID 834428 reaction equation
[CH:28]([OH:29])([CH3:30])[CH3:31].[Cl:17][c:18]1[cH:19][c:20]([NH2:21])[cH:22][cH:23][c:24]1[F:25].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[cH:7][cH:8][c:9](-[n:12]3[cH:13][n:14][cH:15][cH:16]3)[cH:10][c:11]12.[NH4+:26].[OH-:27].[OH2:32]>>[c:2]1([NH:21][c:20]2[cH:19][c:18]([Cl:17])[c:24]([F:25])[cH:23][cH:22]2)[n:3][cH:4][n:5][c:6]2[cH:7][cH:8][c:9](-[n:12]3[cH:13][n:14][cH:15][cH:16]3)[cH:10][c:11]12

Participants

7

Reactant 6

HCID 223AmmoniumHCID 961HydroxideHCID 962WaterHCID 3776IsopropanolHCID 97083-Chloro-4-fluoroanilineHCID 218478354-Chloro-6-(1-imidazolyl)quinazoline

Product 1

HCID 218478184-(3-Chloro-4-fluoroanilino)-6-(1-imidazolyl)quinazoline

Sources & evidence

ORD record
ord-69db9f405e86465ab63b0ee9ef9b008e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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