Dichloromethane → 4-Hydroxy-4-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-1-sulfonamide

HRID 834793Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][S:8](=[O:9])(=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([c:17]2[s:18][c:19](-[c:22]3[cH:23][c:24]([CH3:39])[cH:25][c:26]([NH:28][c:29]4[n:30][cH:31][cH:32][c:33]([C:35]([F:36])([F:37])[F:38])[n:34]4)[cH:27]3)[cH:20][n:21]2)([OH:40])[CH2:15][CH2:16]1)([CH3:5])([CH3:6])[CH3:41].[Cl:49][CH2:50][Cl:51].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48]>>[NH2:7][S:8](=[O:9])(=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([c:17]2[s:18][c:19](-[c:22]3[cH:23][c:24]([CH3:39])[cH:25][c:26]([NH:28][c:29]4[n:30][cH:31][cH:32][c:33]([C:35]([F:36])([F:37])[F:38])[n:34]4)[cH:27]3)[cH:20][n:21]2)([OH:40])[CH2:15][CH2:16]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 58456421Tert-butyl({4-hydroxy-4-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}-phenyl)-1,3-thiazol-2-yl]piperidin-1-yl}sulfonyl)carbamate

Product 1

HCID 584562224-Hydroxy-4-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-1-sulfonamide

Sources & evidence

ORD record: ord-10d5693532fa41f28209eeace19080ed
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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