反应详情

To a solution of itaconic acid (65.3 g) in toluene (400 ml) was added a solution of 2,4-dimethoxybenzylamine (84.0 g) in toluene (100 ml), and the mixture was stirred for 15 hours at reflux. This reaction solution was cooled to room temperature, and concentrated under reduced pressure. To the resulting residue was added diethyl ether (600 ml), and the mixture was stirred. The precipitated solid was collected by filtration, washed with diethyl ether and a small amount of ethyl acetate, and then dried under reduced pressure to give the titled compound (127 g).

1. temperatureat reflux
2. concentrationconcentrated under reduced pressure
3. additionTo the resulting residue was added diethyl ether (600 ml)
4. stirringthe mixture was stirred
5. filtrationThe precipitated solid was collected by filtration
6. washwashed with diethyl ether
7. dry with materiala small amount of ethyl acetate, and then dried under reduced pressure