Dichloromethane → (1-{1-[6-(3,4-Difluoro-phenoxy)-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl]-2,2-dimethyl-propylcarbamoyl}-ethyl)-methyl-carbamic acid benzyl ester
Reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]2[CH:10]([CH:11]([O:13][c:14]3[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]3)[CH2:12]1)[N:22]([C:25]([CH:26]([C:27]([CH3:28])([CH3:29])[CH3:30])[NH:31][C:32]([CH:33]([CH3:34])[N:35]([CH3:36])[C:37](=[O:38])[O:39][CH2:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1)=[O:47])=[O:48])[CH2:23][CH2:24]2)([CH3:5])([CH3:6])[CH3:7].[Cl:56][CH2:57][Cl:58].[F:49][C:50]([F:51])([F:52])[C:53]([OH:54])=[O:55]>>[NH:8]1[CH:9]2[CH:10]([CH:11]([O:13][c:14]3[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]3)[CH2:12]1)[N:22]([C:25]([CH:26]([C:27]([CH3:28])([CH3:29])[CH3:30])[NH:31][C:32]([CH:33]([CH3:34])[N:35]([CH3:36])[C:37](=[O:38])[O:39][CH2:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1)=[O:47])=[O:48])[CH2:23][CH2:24]2Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-c4cdb4e3ec7e454e9bee43e08aa373fd
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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