Hydrochloric Acid → HCID 63362718, compound

HRID 83509Notes

Reaction equation

HRID 83509 reaction equation
C[O:2][C:3]([CH:5]1[CH2:10][CH2:9][C:8](=[O:11])[N:7]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=2[O:21][CH3:22])[CH2:6]1)=[O:4].[OH-].[Na+].Cl>CO.O1CCCC1>[CH3:22][O:21][C:14]1[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:13]=1[CH2:12][N:7]1[C:8](=[O:11])[CH2:9][CH2:10][CH:5]([C:3]([OH:4])=[O:2])[CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 712878151-(2,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic Acid Methyl Ester

Product 1

HCID 63362718HCID 63362718, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a solution of the crude product of 1-(2,4-dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid methyl ester (26.8 g) in methanol/tetrahydrofuran (1/1, 174 ml) was added a 1M aqueous solution of sodium hydroxide (174 ml) at room temperature, and the mixture was stirred overnight. To this reaction solution was added a 1M aqueous solution of hydrochloric acid (174 ml), the mixture was stirred. The precipitated solid was collected by filtration, washed with water, and dried under reduced pressure to give the titled compound (15.1 g).

Workup

  1. stirringthe mixture was stirred
  2. filtrationThe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-38d5c462fad6404ebdb90f7e3dbf0640
Source dataset
uspto-grants-2014_09
Patent number
US08846746B2

Reaction notes

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