Dichloromethane → Trifluoroacetic acid

HRID 835143Notes

Reaction equation

HRID 835143 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][N:10]([CH:12]2[CH2:13][CH2:14][CH:15]([c:18]3[n:19][o:20][c:21]([C:23]([Cl:24])([Cl:25])[Cl:26])[n:22]3)[CH2:16][CH2:17]2)[CH2:11]1)([CH3:5])([CH3:6])[CH3:27].[Cl:35][CH2:36][Cl:37].[F:28][C:29]([C:30](=[O:31])[OH:32])([F:33])[F:34]>>[F:28][C:29]([C:30](=[O:31])[OH:32])([F:33])[F:34].[NH2:7][CH:8]1[CH2:9][N:10]([CH:12]2[CH2:13][CH2:14][CH:15]([c:18]3[n:19][o:20][c:21]([C:23]([Cl:24])([Cl:25])[Cl:26])[n:22]3)[CH2:16][CH2:17]2)[CH2:11]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59541793{1-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-yl}-carbamic acid tert-butyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 595418221-[4-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-cyclohexyl]-azetidin-3-ylamine

Sources & evidence

ORD record
ord-fee4346b672e44cbb78c106f64d4fd7d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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