HCID 86680359, compound → (R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester

HRID 83518Notes

Reaction equation

HRID 83518 reaction equation
[C:1]([O:5][C:6]([C@H:8]1[CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[C:10](=[O:23])[N:9]1[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6]([C@H:8]1[CH2:12][NH:11][C:10](=[O:23])[N:9]1[CH3:24])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 86680359HCID 86680359, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86680358(R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl EsterYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (R)-3-methyl-2-oxoimidazolidine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester (167 mg) in methanol (1.7 ml) was added 10 wt % palladium on carbon at room temperature, and the mixture was stirred for 15 hours under one atom. of hydrogen. Under nitrogen atmosphere, this reaction solution was filtered through Celite, and eluted with methanol. The filtrate was concentrated under reduced pressure to give the titled compound (94 mg).

Workup

  1. filtrationUnder nitrogen atmosphere, this reaction solution was filtered through Celite
  2. washeluted with methanol
  3. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0eb9d5403b344898ad5f9e392dd915fa
Source dataset
uspto-grants-2014_09
Patent number
US08846746B2

Reaction notes

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