反应详情

To a solution of (R)-3-methyl-2-oxoimidazolidine-4-carboxylic acid tert-butyl ester (94 mg) in chloroform (2 ml) was added trifluoroacetic acid (1 ml) at room temperature, and the mixture was stirred for 3 hours. This reaction solution was concentrated under reduced pressure, additional toluene (3 ml) was added thereto, and the mixture was again concentrated. To the resulting residue was added diethyl ether (0.5 ml) at room temperature, and the mixture was stirred. Next, n-hexane (2 ml) was added thereto, and the mixture was further stirred. The insoluble substance was collected by filtration, and dried under reduced pressure to give the titled compound (52 mg).

1. concentrationThis reaction solution was concentrated under reduced pressure, additional toluene (3 ml)
2. additionwas added
3. concentrationthe mixture was again concentrated
4. additionTo the resulting residue was added diethyl ether (0.5 ml) at room temperature
5. stirringthe mixture was stirred
6. additionNext, n-hexane (2 ml) was added
7. filtrationThe insoluble substance was collected by filtration
8. customdried under reduced pressure