2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- → Ethyl 6-iodo-1,2-dihydro-2-(trifluoromethyl)-3-quinolinecarboxylate

HRID 835265Notes

Reaction equation

HRID 835265 reaction equation
[CH3:22][N:23]1[CH2:24][CH2:25][CH2:26][N:27]([CH3:28])[C:29]1=[O:30].[F:11][C:12]([CH:13]=[CH:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])([F:20])[F:21].[I:1][c:2]1[cH:3][cH:4][c:5]([NH2:10])[c:6]([CH:7]=[O:8])[cH:9]1>>[I:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:9]1)[CH:7]=[C:14]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[CH:13]([C:12]([F:11])([F:20])[F:21])[NH:10]2

Participants

4

Reactant 3

HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-HCID 141226Ethyl 4,4,4-trifluorobut-2-enoateHCID 142210302-Amino-5-iodobenzaldehyde

Product 1

HCID 21883508Ethyl 6-iodo-1,2-dihydro-2-(trifluoromethyl)-3-quinolinecarboxylate

Sources & evidence

ORD record
ord-fd73376af0e34d919e98996071037e0e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…