反应详情

To a solution of 1-(4-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine (about 0.277 mmol) prepared in the previous step in chloroform (1 ml) were sequentially added (R)-2-oxoimidazolidine-4-carboxylic acid (40 mg) and WSC.HCl (64 mg) at room temperature, and the mixture was stirred for 3 hours. This reaction mixture was purified by silica gel thin-layer chromatography (eluent: chloroform/methanol=10/1). To the resulting solid were added water and a small amount of methanol, and the mixture was stirred. A solid was collected from this suspension by filtration and was dried under reduced pressure to give the titled compound (56 mg).

1. customat room temperature
2. customThis reaction mixture was purified by silica gel thin-layer chromatography (eluent: chloroform/methanol=10/1)
3. additionTo the resulting solid were added water
4. stirringa small amount of methanol, and the mixture was stirred
5. filtrationA solid was collected from this suspension by filtration
6. customwas dried under reduced pressure