Acetonitrile → 5-chloro-2-[4-[[3-hydroxy-1-[6-(trifluoromethyl)-3-pyridinyl]propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile

HRID 835593Notes

Reaction equation

HRID 835593 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[CH2:8][CH2:9][N:10]([c:12]1[c:13]([C:14]#[N:15])[cH:16][c:17]([Cl:20])[cH:18][cH:19]1)[CH2:11]2.[CH3:45][C:46]#[N:47].[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[NH2:21][CH:22]([CH2:23][CH2:24][OH:25])[c:26]1[cH:27][n:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]1>>[c:2]1([NH:21][CH:22]([CH2:23][CH2:24][OH:25])[c:26]2[cH:27][n:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[CH2:8][CH2:9][N:10]([c:12]1[c:13]([C:14]#[N:15])[cH:16][c:17]([Cl:20])[cH:18][cH:19]1)[CH2:11]2

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 581035883-Amino-3-[6-(trifluoromethyl)pyridin-3-yl]propan-1-olHCID 598406952-(4-bromo-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-chlorobenzonitrile

Product 1

HCID 1785098965-chloro-2-[4-[[3-hydroxy-1-[6-(trifluoromethyl)-3-pyridinyl]propyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]benzonitrile

Sources & evidence

ORD record
ord-89dc3dc0b11f4d6e90a6b3dea05c3d6d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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