Tetrahydrofuran → N-[5-bromo-3-methyl-1-(4-methylphenyl)sulfonylindazol-6-yl]-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide

HRID 835614Notes

Reaction equation

HRID 835614 reaction equation
[Br:20][c:21]1[cH:22][c:23]2[c:24]([CH3:43])[n:25][n:26]([S:33](=[O:34])(=[O:35])[c:36]3[cH:37][cH:38][c:39]([CH3:42])[cH:40][cH:41]3)[c:27]2[cH:28][c:29]1[N:30]=[C:31]=[O:32].[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:15][CH2:16][CH2:17][CH2:18][Li:19].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[NH:9][CH:10]=[CH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[N:9]([C:31]([NH:30][c:29]3[c:21]([Br:20])[cH:22][c:23]4[c:24]([CH3:43])[n:25][n:26]([S:33](=[O:34])(=[O:35])[c:36]5[cH:37][cH:38][c:39]([CH3:42])[cH:40][cH:41]5)[c:27]4[cH:28]3)=[O:32])[CH:10]=[CH:11][C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 593777255-bromo-6-isocyanato-3-methyl-1-(toluene-4-sulfonyl)-1H-indazoleHCID 669062792-(4-fluorophenyl)-2,3-dihydro-1H-pyridin-4-oneHCID 178418339Butyllithium

Product 1

HCID 72281565N-[5-bromo-3-methyl-1-(4-methylphenyl)sulfonylindazol-6-yl]-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide

Sources & evidence

ORD record
ord-9069b21e5b5d4b2c844758c579de1279
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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