反应详情

温度

65 °C

To a solution of methyl acetoacetate (3 ml) in acetone (30 ml) were sequentially added potassium carbonate (11.54 g) and 1,2-dibromoethane (2.4 ml) at room temperature, and the mixture was stirred at 65° C. for 17 hours. This reaction mixture was filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=10/1) to give the titled compound (2.17 g).

1. customat room temperature
2. filtrationThis reaction mixture was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. customthe resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=10/1)